Hypercalcemia 的定義

---------- Forwarded message ----------
From: bryan;

Dear all,

M&M報完回去重新查了一次hypercalcemia的定義
在正常的情況下 ionized Ca佔大約50%
但是到Ca濃度越高 因為能夠結合的albumin根本就全部被佔滿了
所以ionized Ca的level就會越來越接近total calcium的level

In plasma, calcium exists in 3 different forms,

• (1) 50% as ionized or the biologically active form,
• (2) 45% bound to plasma proteins (mainly albumin), and
• (3) 5% complexed to phosphate and citrate

Hypercalcemia:

• Mild: Total Ca 10.5-11.9 mg/dL (2.5-3 mmol/L) or Ionized Ca 5.6-8 mg/dL (1.4-2 mmol/L)
• Moderate: Total Ca 12-13.9 mg/dL (3-3.5 mmol/L) or Ionized Ca 8-10 mg/dL (2-2.5 mmol/L)
• Hypercalcemic crisis: Total Ca 14-16 mg/dL (3.5-4 mmol/L) or Ionized Ca 10-12 mg/dL (2.5-3 mmol/L)

子堯