What types of malaria chemoprophylaxis would be safe for a pregnant woman?
Malaria is more severe in pregnancy, and the risks of adverse outcomes (for both the mother and the fetus) are increased. No chemoprophylactic agent is 100% effective. The WHO and the CDC both recommend that pregnant women not travel to areas where malaria is endemic. Most women refrain from traveling to these areas during pregnancy, but for pregnant women who decide to travel or must travel, mefloquine is the drug of choice for chloroquine-resistant malaria. (Chloroquine can also be used during pregnancy.)
New England Journal of Medicine - Vol. 359, No. 6, August 7, 2008